Jeff is a giant spider with the ability to speak and behave like a human. Other giant spiders are seen in Wrath of the Spider Queen.
Half Spiders have the upper body of a non-spider (such as a human in Velma's case) and the lower body of a spider.
- Arachnotaur is half cow, half spider, but since he is considered a spider god, he is unlikely to be part of a hybrid species.
- Spiderpox victims turn into human-spider hybrids.
- The Spider-Clown Mailman was an illusion created by The Left Hand of Horror
In Wrath of the Spider Queen the spiders took over the school and cocooned everything in it.. In a flashback, Velma Green summoned spiders for her audition and they attacked the audience. One spider cocooned a victim and another spider came down from a web and grabbed the cocooned victim away.