The following is a list of deceased people who had an affiliation with the making of Grim & Evil and their spin-offs shows The Grim Adventures of Billy & Mandy and Evil Con Carne.
- John Vernon - Died on February 1, 2005, He was originally the voice of Toadblatt.
- Hamilton Camp - Died on October 2, 2005, He was the voice of Country Dirty Gnome.
- Mako Iwamatsu - Died on July 21, 2006, He was the voice of the Narrator.
- Greg Burson - Died on July 22, 2008. He was the voice of Yogi Bear.
- Henry Gibson - Died on September 14, 2009, he was the voice of Lord Pain.
- Michael Gough - Died on March 17, 2011, he was the voice of Daisy the Chupacabra.
- Ian Abercrombie - Died on January 26, 2012, He was the voice of F.
- John Cygan - Died on May 13, 2017, He was the voice of TV Announcer.
- Barry Dennen - Died on September 26, 2017, He was the voice of the Salesperson.
- R. Lee Ermey - Died on April 15, 2018, He was the voice of the prison warden in "Here Thar Be Dwarves!."
- Chris Reccardi - Died on May 2, 2019, He was a writer and storyboard director.
- Michael Lindsay - Died on August 31, 2019, He was the voice of Bobby.
- Rip Taylor - Died on October 6, 2019, He was the voice of Larry.
- Fred Willard - Died on May 15, 2020, he was the voice of Boogeyman.
- David Lander - Died on December 4, 2020. He was the voice of Billy's brain in "The Nerve" and Curtis in Wrath of the Spider Queen.