The following is a list of deceased people who had an affiliation with the making of Grim & Evil and their spin-offs shows The Grim Adventures of Billy & Mandy and Evil Con Carne.
- Greg Burson - Died on July 22, 2008. He was the voice of Yogi Bear
- R. Lee Ermey - Died on April 15, 2018. He was the voice of the prison warden in "Here Thar Be Dwarves!."
- Chris Reccardi - Died on May 2, 2019. He was a writer and storyboard director.
- Fred Willard - Died on May 15, 2020, he was the voice of Boogeyman.
- David Lander - Died on December 4, 2020. He was the voice of Billy's brain in "The Nerve" and Curtis in Wrath of the Spider Queen.